Mission Hills is a suburban community in the San Fernando Valley region of the city of Los Angeles, California.
It is located near the northern junction of the Golden State Freeway (Interstate 5) and the San Diego Freeway (Interstate 405). The Ronald Reagan Freeway (SR 118) bisects the neighborhood. Mission Hills is the northern terminus of the lengthy Sepulveda Boulevard. Other major thoroughfares include San Fernando Mission Boulevard, Woodman Avenue, and Rinaldi, Brand, Chatsworth, Devonshire, and Lassen Streets. The boundaries are roughly Sepulveda Blvd and Interstate 405 to the west, Interstate 5 to the north and east, Van Nuys Boulevard to the southeast, and Lassen Street to the south. The Granada Hills district lies to the west, Sylmar to the north, the city of San Fernando to the northeast, Pacoima to the east, Arleta to the southeast, and Panorama City to the south. The southern portion of Mission Hills is also considered part of the Sepulveda district of Los Angeles.
The community is notable as the location of Mission San Fernando Rey de España. The Andrés Pico Adobe, the second oldest residence still standing in Los Angeles, is also here. The San Fernando Mission Cemetery is still actively used.
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